Toxic kinetics/ Dose Formulation

Toxic kinetics/ Dose Formulation

Toxic kinetic analysis indicated that the profile (Cmax and T1/2) for the test item did not differ. Dose formulation analysis indicated that the doses administered were as stated in the study.

Biochemical analysis

Group 1 and 2 values for all parameters were within historical and literature range. In group 3, most of the parameters were within historical and literature range, except slightly elevated alanine aminotransferase (ALT, Aspartate aminotransferase (ASP) and Sorbitol dehydrogenase (SDH). In group 4, values for most parameters were within historical and literature range except significantly high levels of ALT and AST, ALT, AST, and SDH were very high (ALT>AST) in the rats that were euthanized. For the rats that completed the study, parameter values were within historical and literature range.

This type occurs between two or even more persons with a specific person communicating with the others. The message here emanates from a specific individual. It can be done by a person to an audience, or face to face, post, couriers, mobile messages, telephone, or through emails.

It can be classified further as communications from social contacts, expert and advocates. When the company’s sales persons communicate to the customers, this is referred to as communication from the advocates of that product. Expert communication occurs when an independent expert communicates to the prospective buyers about the advantages of the product while social channel communication occurs when a neighbor talks positively about a given brand.

Haematology

White blood differentials were normal in all animals. The haematocrit was elevated in 3 rats that received the low dose but all the other rats had haematocrit within the normal range.

Histology

Light microscopy of tissue sections showed an increase in recruitment of inflammatory cells in the liver. There were no changes in the kidney, spleen, or any other organ examined.

Toxic kinetics/ Dose Formulation

Toxic kinetic analysis indicated that the profile (Cmax and T1/2) for the test item did not differ. Dose formulation analysis indicated that the doses administered were as stated in the study.

Biochemical analysis

Group 1 and 2 values for all parameters were within historical and literature range. In group 3, most of the parameters were within historical and literature range, except slightly elevated alanine aminotransferase (ALT, Aspartate aminotransferase (ASP) and Sorbitol dehydrogenase (SDH). In group 4, values for most parameters were within historical and literature range except significantly high levels of ALT and AST, ALT, AST, and SDH were very high (ALT>AST) in the rats that were euthanized. For the rats that completed the study, parameter values were within historical and literature range.

This type occurs between two or even more persons with a specific person communicating with the others. The message here emanates from a specific individual. It can be done by a person to an audience, or face to face, post, couriers, mobile messages, telephone, or through emails.

It can be classified further as communications from social contacts, expert and advocates. When the company’s sales persons communicate to the customers, this is referred to as communication from the advocates of that product. Expert communication occurs when an independent expert communicates to the prospective buyers about the advantages of the product while social channel communication occurs when a neighbor talks positively about a given brand.

Haematology

White blood differentials were normal in all animals. The haematocrit was elevated in 3 rats that received the low dose but all the other rats had haematocrit within the normal range.