The connective tissue of the pancreas is formed from the surrounding splanchnic mesoderm. The rotation of the stomach, ventral mesentery, and the duodenum push the pancreas to lie in the stomach bed in the posterior abdomen. The pancreas is pushed up by the transverse colon and its peritoneum fuses with that of the posterior abdominal wall making the pancreas a retroperitoneal organ in the stomach bed.
During the third month of fetal life, the parenchymatous tissue of the pancreas gives rise to islets of Langerhans (discrete cell aggregates derived from endoderm) which are scattered throughout the pancreas. Glucagon, Somatostatin and pancreatic polypeptide secreting cells also develop from the parenchyma. This leads to the formation of the endocrine portion of the pancreas with insulin secretion beginning as early as the fifth month of fetal life (Moore and Torchia 23).
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