The TAS2R38 is responsible for the bitter taste experienced when one comes into contact with PTC.3 An analysis of SNP’s nucleotide helps reveal the receptor responsible for this observation. Studies have determined that the G protein-coupled receptor is the one responsible for the experience. In this regard, the PTC acts as the ligand.4 Binding, in this case, results from a process known as molecular docking (see figure 1). Such a process (also known as binding) must occur at a given site. In this case, the receptor activation occurs on helices 6 and 7. It is believed that N103 residue is an active component of PTC binding. The shape and size of the binding cavity are defined by a number of factors. They include W99, M100, and S259. The binding process largely relies on receptor activation. M100, V296, and F255 play a key role in this activation.
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