DDT is an organochloride neurotoxin that alters the rate at which potassium ions get into neurons. It also affects the active transport of sodium ions out neurons when they are repolarized. The organochloride inhibits Na+, K+Â and Ca2+Â ATPase when neurons are repolarized. These actions of the neurotoxin result in prolonged negative phase in the action of the stimuli. The repetitive stimulation in the PNS is further amplified in the CNS, resulting in continuous tremor in the poisoned individual.
Organophosphorous pesticide effects are produced by inhibition of the enzyme acetylcholinesterase, which hydrolyzes acetylcholine. When the enzyme is inhibited, there is prolonged stimulation in cholinergic nerves by the neurotransmitter acetylcholine. Prolonged stimulation of the muscarinic nerve endings leads to hyperactivity of multiple responses in the parasympathetic nervous system. Prolonged action of acetylcholine also causes neurons within the sympathetic and parasympathetic nervous system to be depolarized.
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