Models lack some chromosomes present in human being

The study of pluripotency has its origin from the study of cell biology and cloning in mammals. According to a pluripotency study, primitive embryonic cells from mammals such as mice and monkeys can be used in making whole organisms. However, the generation of animals to be used in the study of neurological diseases in humans has proved difficult. This is because of difficulties in matching the genetic composition of the models with the real organisms.

In addition, the majority of the animals used in the production of models lack some chromosomes present in human beings, for instance, the mouse lacks chromosome 21. To overcome the problem of animal model limitations, everlasting neural cells are used in the culturing of tissue models. However, the use of immortal cells also poses a challenge to the treatment of neurological disorders. For instance, in the use of immortal cells in the production of culture tissues, abnormal cells may be produced. In addition, the disease-expressing genes may be over-expressed.

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According to the research carried out, the generation of iPS cells can aid in generating diverse neurons and neural support cells like those found in the brain and the spinal cord, hence enhancing the containing of neurological diseases. In addition, the development of iPS cell models will be of great advantage to both neurodegenerative and neurodevelopmental diseases. An example of neurodevelopmental disorder is fragile X syndrome.

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