The article â€œSynchronous optical and electrical detection of biomolecules traversing through solid-state nanoporesâ€ is a 2010 publication in theÂ Review of Scientific InstrumentsÂ journal volume 81 from page 014301-7. The article is authored by Soni Gautam V., Singer Alon, Yu Zhiliang, Sun Yingjie, McNally Ben and Mellera Amit. Soni and colleagues discuss a new way of integrating â€œtotal internal reflection microscopy and electrical detection of biomolecules using nanoporesâ€ (p. 1) with both techniques being recognized as modalities of measuring single-molecules. This integration enables visualization of DNA and DNA-protein complexes while they undergo translocation via a nanopore. A good temporal resolution of about 1000 frames is produced while an excellent signal to background is enabled.
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