Considering that the acute toxicity studies on the test item had been conducted earlier and the highest dose determined, it is possible to conduct the oral toxicity studies using repeated doses (Comstock 2008, p. 1010). Thus, the current study was aimed at determining the possible health hazards expected from repeated exposure of rats to the test item.
The current study plan was prepared and used in accordance with the OECD Guideline 407 for the Testing of Chemicals, which was adopted on the 27thÂ July 1995. This guideline provides information on the protocols and considerations used in repeated dose (for 28 days) oral toxicity studies in animals particularly rodents (OECD 1998b; OECD 1998d). The same protocols were replicated in the current study involving rats.
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